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T17731 |
CL2A-SN-38
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Others
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CL2A-SN-38 is a drug-linker conjugate consisting of SN-38, a potent DNA topoisomerase I inhibitor, and linker CL2A, for the manufacture of antibody drug conjugates (ADCs). CL2A-SN-38 provides significant and specific ant... |
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T31011 |
Coralyne chloride
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Topoisomerase
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Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. ... |
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TQ0088 |
Exatecan Mesylate
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DX8951f |
Topoisomerase
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Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL). |
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T68896 |
Daniquidone
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NSC 320846,BAY-H 2049 |
Topoisomerase
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Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity that induces DNA fragmentation for the study of neoplasms, immune disorder... |
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T6336 |
Amonafide
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NSC308847,AS1413,Nafidimide,AS1413,Quinamed |
Topoisomerase
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Amonafide (NSC-308847,AS1413)(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
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T15168 |
DRF-1042
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Topoisomerase
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DRF-1042 is an orally active camptothecin analog with anticancer and insecticidal activity that inhibits DNA topoisomerase I. DRF-1042 has been used in the study of solid tumors, such as prostate and colon cancers. |
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T11249L |
Dxd
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Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ |
Topoisomerase
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Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC. |
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T11872L |
LMP744 hydrochloride
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NSC706744 hydrochloride,MJ-III65 hydrochloride |
Topoisomerase
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T7309 |
TAS-103 dihydrochloride
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TAS-103 (dihydrochloride),BMS-247615 dihydrochloride |
Topoisomerase
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TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II. |
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T11249 |
Exatecan
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DX-8951,DX-8951f |
Topoisomerase
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T17731L |
CL2A-SN-38 DCA 1279680-68-0(free base)
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Others
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CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibito... |
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T29168 |
XR-5000
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NSC-601316,CRC8805,SN-22995,DACA,CRC-8805 |
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XR-5000 is a DNA topoisomerase I and II inhibitor. |
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T15586 |
Intoplicine
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Topoisomerase
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Intoplicine is an inhibitor of DNA topoisomerase I and II. |
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T60766 |
Topoisomerase I inhibitor 3
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Topoisomerase I (Compound ZML-14) inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase. Topoisomerase I inhibitor 3 is an inhibitor of topoisomerase I that interact with topoisomerase I-DNA compl... |
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T11872 |
LMP744
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NSC706744,MJ-III65 |
Others
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LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. |
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T70445 |
Lurtotecan dihydrochloride
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Lurtotecan dihydrochloride is an antineoplastic (DNA Topoisomerase I Inhibitor) |
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T40365 |
T-2513
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T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA r... |
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T60617 |
Topoisomerase I inhibitor 2
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Topoisomerase I inhibitor 2 (ZML-8) is a highly selective DNA topoisomerase I (Top1) inhibitor that inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis with ... |
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T26339 |
XR-11576
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MLN-576,MLN 576,MLN576,XR 11576 |
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XR-11576 is a DNA topoisomerase I and II inhibitor for the treatment of solid tumors. |
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T39373 |
PNU-EDA-Gly5
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PNU-EDA-Gly5 |
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PNU-EDA-Gly5 is a DNA topoisomerase I inhibitor-based oligo-glycine linker-payload used for the synthesis of antibody-drug conjugates (ADCs). It consists of the DNA topoisomerase I inhibitor PNU-159682 and the linker EDA... |
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T69838 |
NB-506 glucuronide
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NB-506 glucuronide is an indolocarbazole antitumor agent; a DNA topoisomerase I inhibitor. |
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T63225 |
T-2513 hydrochloride
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T-2513 hydrochloride is a selective inhibitor of topoisomerase I. T-2513 hydrochloride covalently binds to the topoisomerase I-DNA complex, maintains its stability, and is able to inhibit DNA replication and RNA synthesi... |
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T70513 |
NB-506 Free Base
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NB-506 Free Base is an indolocarbazole antitumor agent; a DNA topoisomerase I inhibitor. |
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T28982 |
TLC 388
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TLC-388,TLC388 |
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TLC 388, a DNA topoisomerase I inhibitor, is used potentially for the treatment of Renal carcinoma and Hepatocellular carcinoma |
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T72727 |
Huanglongmycin N
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Huanglongmycin N acts as a DNA topoisomerase I inhibitor, demonstrating an EC50 value of 14 μM. |
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T15200 |
Edotecarin
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PF 804950,J 107088 |
Topoisomerase
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T61501 |
Topoisomerase I inhibitor 5
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Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and... |
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T78630 |
Exatecan mesylate dihydrate
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DX-8951 mesylate dihydrate |
Topoisomerase
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Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3]. |
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T62094 |
Topoisomerase I inhibitor 6
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Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I that traps the DNA-Top1 cleavage complex and has low cytotoxicity in non-cancerous cell lines. Research value. |
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T10832 |
CL2-SN-38
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Others
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CL2-SN-38, a part of the antibody-drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is an inhibitor of DNA topoisomerase I. |
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T36700 |
CKD 602
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Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian ... |
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T61045 |
Topoisomerase I/II inhibitor 2
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Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual i... |
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T74724 |
MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan
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MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan is a agent-linker conjugates for ADC , consisting Exatecan . Exatecan is a DNA Topoisomerase I inhibitor (IC 50 =2.2 μM) [1] . |
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T23654 |
Afeletecan free base
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BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan |
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Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps ... |
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T18538 |
MAC glucuronide phenol-linked SN-38
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Others
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MAC glucuronide phenol-linked SN-38, a pH-sensitive lactone and DNA topoisomerase I inhibitor drug linker, exhibits cytotoxicity in L540cy and Ramos cells, with IC50 values of 113 ng/mL and 67 ng/mL, respectively[1]. |
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T38731 |
Intoplicine dimesylate
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RP 60475 dimesylate |
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Intoplicine (RP 60475) dimesylate is a DNA topoisomerase I and II inhibitor belonging to the 7H-benzo[e]pyrido[4,3-b]indole series. It exhibits a strong affinity for DNA (K A = 2 x 10^5 /M), resulting in increased linear... |
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T74723 |
MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan
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MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is an agent-linker conjugate for antibody-drug conjugates (ADCs), incorporating Exatecan, a DNA Topoisomerase I inhibitor (IC 50 = 2.2 μM) [1]. |
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T27141 |
Delimotecan
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MEN4901,MEN 4901,T-0128,MEN-4901,T 0128 |
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Delimotecan is a DNA topoisomerase I inhibitor. Delimotecan had a long terminal half-life of 109 h, and relatively high exposures to T-2513 and SN-38 were obtained. The percentage decrease in WBC and absolute neutrophil ... |
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T79883 |
9-Chloromethyl-10-hydroxy-11-F-Camptothecin
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Topoisomerase
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9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential applications in anticancer research [1]. |
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T16024 |
MC-GGFG-DX8951
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Others
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MC-GGFG-DX8951 is a drug-linker conjugate designed for antibody-drug conjugation (ADC) that demonstrates antitumor activity through the deployment of DX8951, a DNA topoisomerase I inhibitor, connected using the protease-... |
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T38962 |
MC-SN38
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MC-SN38 |
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MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs). SN38, the active metabolite of the Topoisome... |
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T62435 |
Belotecan
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Belotecan (CKD-602 free base) is an inhibitor of DNA topoisomerase I. Belotecan blocks the cell cycle and induces apoptosis and is an antitumour derivative of camptothecin that can be used in cancer research. |
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T14945 |
CH-0793076
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TP3076 |
Topoisomerase
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CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisome... |
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T77901 |
Ac-Exatecan
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Topoisomerase
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Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug conjugate (ADC) formulations (ADC Cytotoxin) and acts as an inhibitor of DNA topoisomerase I with an IC50 val... |
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T77889 |
NH2-methylpropanamide-Exatecan TFA
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Topoisomerase
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Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.975 μg/mL), utilized in the synthesis of ADCs for cancer res... |
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T68207 |
Elsamitrucin
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Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I a... |
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T77891 |
Propargyl-PEG4-GGFG-DXd
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Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising an ADC linker and the DNA topoisomerase I inhibitor known as DXd [1]. |
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T77882 |
SN38-COOH
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SN38-COOH, the active metabolite of the topoisomerase I inhibitor irinotecan, is utilized in the synthesis of antibody-drug conjugates (ADCs). It functions by inhibiting DNA and RNA synthesis [1] [2]. |
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T74735 |
Gly-Cyclopropane-Exatecan
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Gly-Cyclopropane-Exatecan, a DNA Topoisomerase I inhibitor containing Exatecan, is key in synthesizing the anti-B7-H4 ADC, specifically the ADC hu2F7-Exatecan (compound 34). This compound demonstrated antitumor activity ... |
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T36485 |
Becatecarin
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Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition... |
